| Ryan, Derby | Surry (1); 50 acres, 1804 |
| Ryan, Edward | Guilford (1); 640 acres, 1780 |
| Ryan, George | Bertie (5); 1990 acres, 1787 |
| Ryan, George L. | Bertie (1); 0 acres, 1820 |
| Ryan, Hiram | Wilkes (1); 150 acres, 1821 |
| Ryan, James | Currituck (4), Sampson (2), Guilford (1), plus 1 grant in 1 other county; total 8 grants and 1433 acres, 1782-1795 |
| Ryan, Jeffrey | Sumner TN (1); 228 acres, 1797 |
| Ryan, John | Surry (6), Randolph (2), Washington TN (1), plus 1 grant in 1 other county; total 10 grants and 1783 acres, 1782-1817 |
| Ryan, Patrick | Richmond (1); 100 acres, 1799 |
| Ryan, Peter | Sampson (1); 48 acres |
| Ryan, Thomas | Bertie (4); 240 acres, 1740 |
| Ryan, William | Middle District TN (1), Bertie (1); total 2 grants and 32206 acres, 1787-1795 |
| Ryann, George L. | Tyrrell (2); 46 acres, 1819 |
| Ryans Swamp | Bladen (1); 150 acres, 1779 |
| Ryans, James | Currituck (1); 400 acres |
| Ryborn, Jacob | Buncombe (1); 50 acres, 1798 |
| Rycard, David | Caldwell (1); 100 acres, 1890 |
| Rye Branch | Sampson (1), Burke (1); total 2 grants and 250 acres, 1800-1831 |
| Rye Cove | Ashe (2); 250 acres, 1806-1847 |
| Rye Cove Branch | Buncombe (3); 400 acres, 1807-1835 |
| Rye Field Branch | Buncombe (1); 300 acres |
| Rye Field Gap | Ashe (1); 50 acres, 1845 |
| Rye Ridge | Ashe (4); 910 acres, 1831-1840 |
| Rye Swamp | Duplin (3), Sampson (2); total 5 grants and 862 acres, 1782-1852 |
| Rye, Absalom | Richmond (1); 150 acres, 1787 |
| Rye, Dun | Richmond (1); 50 acres, 1795 |
| Rye, Dunn | Anson (1); 150 acres, 1780 |
| Rye, John | Richmond (1), Anson (1); total 2 grants and 144 acres, 1780-1813 |
| Rye, Joseph | Anson (4); 500 acres, 1773-1780 |
| Rye, Solomon | Anson (1); 100 acres, 1780 |
| Ryefield Branch | Graham (1), Burke (1); total 2 grants and 125 acres, 1831-1883 |
| Ryen, William | Burke (1); 250 acres, 1792 |
| Ryes Branch | Sampson (1); 200 acres, 1793 |
| Ryle, James | Anson (1); 200 acres, 1770 |
| Ryle, John | Anson (1); 200 acres, 1774 |
| Ryles, John | Anson (1); 1 acres, 1820 |
| Ryley, James | Davidson (1); 110 acres, 1829 |
| Ryley, John | Bladen (1); 300 acres |
| Ryley, Nathan | Rowan (3); 175 acres, 1807-1820 |
| Ryley, Rhodias | Rowan (1); 40 acres, 1820 |
| Ryley, Robert | Craven (2); 400 acres, 1747 |
| Ryley, William | Rowan (1); 200 acres, 1784 |
| Ryly's Branch | Johnston (2); 500 acres, 1754 |
| Rymer, A. | Buncombe (1); 29 acres, 1882 |
| Rymer, David | Buncombe (4); 490 acres, 1803 |
| Rymer, Eli | Buncombe (1); 50 acres, 1815 |
| Rymer, James M. | Graham (1); 219 acres, 1891 |
| Rymer, Nicholas | Rowan (1); 14 acres, 1829 |
| Rynalds, Harmond | Guilford (1); 300 acres, 1782 |
| Ryndles, William | Lincoln (1); 90 acres, 1802 |
| Ryne, Christian | Lincoln (1); 1 acres, 1823 |
| Ryne, Jacob | Lincoln (2); 61 acres, 1787-1823 |
| Ryne, Peter | Lincoln (1); 29 acres, 1823 |
| Ryne, Thomas | Lincoln (2); 204 acres, 1789-1825 |
| Ryner, David | Buncombe (1); 150 acres, 1836 |
| Ryner, Eli | Buncombe (1); 50 acres, 1841 |
| Rynolds, Frances | Wilkes (1); 150 acres, 1798 |
| Rynolds, Matthew | Sampson (1); 150 acres, 1797 |
| Ryon, John | Surry (1); 100 acres, 1805 |
| Ryon, Patrick | Richmond (1); 100 acres, 1799 |
| Ryon, William | Greene TN (1); 100 acres, 1786 |
| Ryons Creek | Guilford (1); 150 acres, 1787 |
| Rysdon, William | Wilkes (1); 100 acres, 1788 |
| Ryser, George | Lincoln (1); 100 acres, 1794 |
| Ryson, James | Bladen (1); 180 acres, 1789 |
| Sa Wa Gah | Macon (3); 164 acres |
| Sabastin, William | Wilkes (1); 150 acres, 1810 |
| Sabaston, David | Carteret (1); 50 acres, 1804 |
| Sabiston, John, Jr. | Carteret (1); 100 acres, 1842 |
| Sabiston, William B. | Carteret (2); 60 acres, 1854 |
| Sackets Branch | Ashe (1); 50 acres, 1836 |
| Sacrut, Francis | Mecklenburg (1); 52 acres, 1813 |
| Sadberry, Stockley | New Hanover (1); 100 acres, 1808 |
| Sadberry, William | Montgomery (1); 50 acres, 1818 |
| Sadbery, William | Montgomery (1); 300 acres, 1809 |
| Sadbury, George | New Hanover (2); 740 acres, 1812 |
| Sadbury, James | New Hanover (2), Onslow (1); total 3 grants and 830 acres, 1737-1807 |
| Sadbury, John | New Hanover (3); 350 acres, 1829 |
| Sadbury, John, Jr. | New Hanover (1); 80 acres, 1833 |
| Sadbury, Stockley | New Hanover (1); 50 acres, 1808 |
| Sadbury, William | New Hanover (1); 55 acres |
| Sadbury, Woodman Lockly | New Hanover (1); 300 acres, 1737 |
| Sadbury, Woodman Stockly | New Hanover (1); 300 acres, 1737 |
| Saddle Gap | Ashe (2); 120 acres, 1840-1842 |
| Saddle Gap Branch | Ashe (7); 665 acres, 1831-1913 |
| Saddle Mountain | Surry (2), Ashe (2), Alleghany (1); total 5 grants and 517 acres, 1746-1936 |
| Saddle Mountain Creek | Surry (11), Ashe (1); total 12 grants and 516 acres, 1830-1891 |
| Saddlemire, Jacob | Burke (1); 150 acres, 1782 |
| Saddlemore, Jacob | Burke (1); 100 acres, 1782 |
| Saddler, Phillip | Mecklenburg (1); 16 acres, 1832 |
| Saddletree Swamp | Bladen (49), Robeson (40); total 89 grants and 14064 acres, 1753-1816 |
| Sade Branch | Buncombe (1); 100 acres |
| Sadler, Ellenorr | Chowan (1); 252 acres, 1715 |
| Sadler, George | Tryon (1); 260 acres, 1771 |
| Sadler, Henry | Mecklenburg (3); 370 acres, 1772-1775 |
| Sadler, John | Hyde (3), Tryon (1); total 4 grants and 1440 acres, 1769-1803 |
| Sadler, Mary | Tryon (1), Mecklenburg (1); total 2 grants and 200 acres, 1769 |
| Sadler, Philip | Mecklenburg (1); 5 acres, 1804 |
| Sadler, Phillip | Mecklenburg (1); 20 acres, 1802 |
| Sadler, Richard | Tryon (2), Mecklenburg (1); total 3 grants and 595 acres, 1767-1772 |
| Sadler, Stephen | Hyde (1); 50 acres, 1805 |
| Sadler, William R. | Lincoln (4); 235 acres, 1799-1819 |
| Sadlers Branch | Tryon (1), Guilford (1); total 2 grants and 800 acres, 1772-1789 |
| Sadowsky, Emanuel | Washington TN (1); 640 acres, 1784 |
| Safer, Leonard | Mecklenburg (1); 300 acres, 1763 |
| Saferight, Henry | Guilford (1); 24 acres, 1800 |
| Safferet, Leonard | Anson (2); 600 acres, 1761 |
| Saffold, William | Tryon (1); 200 acres |
| Safley, David | Montgomery (7), Stanly (1); total 8 grants and 761 acres, 1818-1846 |
| Safley, Jessee | Montgomery (1); 100 acres |
| Safley, William B. | Stanly (2); 64 acres, 1848-1852 |
| Safley, Willis | Stanly (1); 30 acres, 1848 |
| Safly, David | Montgomery (1); 99 acres, 1844 |
| Safly, W. B. | Stanly (1); 16 acres, 1852 |
| Safoy, James | Surry (1); 300 acres, 1784 |
| Sage Creek | Surry (3), Wake (1); total 4 grants and 285 acres, 1807-1904 |
| Sage Island | Brunswick (1); 0 acres, 1923 |
| Sage's Ridge | New Hanover (1); 100 acres |
| Sage, Edward | Sumner TN (1); 640 acres, 1793 |
| Sage, Robert | New Hanover (3), Onslow (1); total 4 grants and 600 acres, 1769 |
| Sailers Branch | Tryon (2); 400 acres, 1775 |
| Sailes, Theophilus | Buncombe (1); 100 acres, 1836 |
| Sailor, Conrod | Mecklenburg (1); 200 acres |
| Sailor, George | Rutherford (1); 150 acres, 1789 |
| Sailor, John | Burke (1); 300 acres, 1782 |
| Sailor, Michael | Burke (1); 330 acres, 1782 |
| Sailor, Peter | Tryon (1), Lincoln (1); total 2 grants and 400 acres, 1803 |
| Sails, Lenard | Wilkes (1); 309 acres, 1784 |
| Sails, Lennard | Wilkes (1); 720 acres, 1784 |
| Sails, Thomas | Wilkes (1); 200 acres, 1791 |
| Saim, John | Rowan (1); 640 acres, 1759 |
| Sain, Daniel | Catawba (1); 3 acres, 1910 |
| Sain, W. R. | Lincoln (1); 2 acres, 1921 |
| Sains, Casper | Rowan (1); 200 acres, 1795 |
| Saint Clair Lump | Dare (1); 2 acres, 1921 |
| Saint Clair, Hiram | Buncombe (1); 35 acres, 1857 |
| Saint Clair, James H. | Alexander (1); 16 acres, 1881 |
| Saint Clair, John E. | Wilkes (1); 100 acres, 1854 |
| Saint Clair, Leander | Alexander (1); 40 acres, 1910 |
| Saint Clair, Thomas H. | Wilkes (1); 100 acres, 1854 |
| Saint Clear, Thomas Crawford | Buncombe (1); 100 acres |
| Saint George, Edward | New Hanover (2); 812 acres, 1815 |
| Saint George, Elijah | New Hanover (2); 100 acres, 1796 |
| Saint George, George | New Hanover (1); 200 acres, 1767 |
| Saint George, William | New Hanover (1); 20 acres |
| Saint Georges Street | Halifax (1); 0 acres, 1786 |
| Saint James Parish (N.C.) | New Hanover (1); 640 acres |
| Saint John's Parish (N.C.) | Pasquotank (1); 278 acres, 1761 |
| Saint John, William | Bute (1); 640 acres, 1779 |
| Saint Johns Neck | Chowan (3), Bertie (1); total 4 grants and 2270 acres, 1717-1725 |
| Saint Peter's Lutheran Church | Lincoln (1); 20 acres, 1823 |
| Saint Philips Parish | New Hanover (2); 100 acres, 1754 |
| Saint, Axum | Anson (1); 50 acres, 1804 |
| Saint, Benjamin | Anson (3); 200 acres, 1816-1817 |
| Saint, Isham | Anson (2); 348 acres, 1816 |
| Saint, Samuel | Wayne (2); 253 acres, 1790 |
| Saint, Thomas | Wayne (1); 640 acres, 1783 |
| Saintclair, John | Wilkes (1); 100 acres, 1829 |
| Saintclair, John E. | Wilkes (2); 144 acres, 1847 |
| Saintclair, Leander | Wilkes (1); 60 acres, 1865 |
| Saintclair, Thomas H. | Wilkes (6); 236 acres, 1837-1864 |
| Saintclair, William J. | Wilkes (1); 13 acres, 1860 |
| Saintclare, John E. | Wilkes (1); 100 acres, 1847 |
| Sakes Creek | Stokes (1); 25 acres, 1797 |
| Sal's Branch | Swain (1); 22 acres, 1897 |
| Salde, Pugh | Martin (1); 320 acres, 1817 |
| Sale, Barney | Stokes (1); 166 acres, 1797 |
| Sale, Cornelius | Wilkes (4); 555 acres, 1782-1800 |
| Sale, Robert | Wilkes (2); 103 acres, 1797-1902 |
| Sale, Thomas | Wilkes (1); 100 acres, 1789 |
| Sale, William | Wilkes (2); 180 acres, 1785 |
| Salem Road | Surry (4); 502 acres, 1779-1790 |
| Salem Township | Pasquotank (1); 3 acres |
| Salemone Branch | Onslow (1); 75 acres, 1762 |
| Saler, Joseph | Mecklenburg (1); 180 acres, 1767 |
| Salers Branch | Tryon (1), Lincoln (1); total 2 grants and 674 acres, 1772-1790 |
| Salers Creek | Lincoln (3); 330 acres, 1787-1804 |
| Sales Branch | Macon (1), Bladen (1); total 2 grants and 300 acres, 1779-1854 |
| Sales Creek | New Hanover (1); 135 acres, 1784 |
| Sales, Elias | Buncombe (1); 100 acres, 1836 |
| Sales, James | Wilkes (1); 200 acres, 1797 |
| Sales, John | Wilkes (1); 100 acres, 1813 |
| Sales, Silas | Wilkes (1); 50 acres, 1872 |
| Sales, W. A. J. | Columbus (1); 30 acres, 1904 |
| Salger, Samuel G. | Tyrrell (2); 125 acres, 1844 |
| Saliers, William | Sumner TN (1); 60400 acres, 1795 |
| Saliers, Zachariah | Tryon (1); 300 acres, 1783 |
| Saline (tenn.) | Tennessee TN (1); 640 acres |
| Saline Creek (tenn.) | Davidson TN (5), Tennessee TN (3), Montgomery TN (1); total 9 grants and 5748 acres, 1787-1797 |
| Saling, George Adam | Orange (1); 470 acres, 1761 |
| Salisberry, John | Craven (1); 0 acres |
| Salisbury | Rowan (37), Rockingham (1), Guilford (1); total 39 grants and 5530 acres, 1755-1900 |
| Salisbury Plains | Anson (1); 200 acres, 1779 |
| Salisbury Road | Montgomery (2), Surry (1), Stanly (1), plus 1 grant in 1 other county; total 5 grants and 508 acres, 1780-1852 |
| Salisbury, Andrew | Johnston (2); 600 acres, 1761 |
| Salisbury, John | Rowan (1); 370 acres, 1791 |
| Salkield, Isaac | Sampson (1); 50 acres, 1788 |
| Salkins, Isaac | Sampson (1); 90 acres, 1787 |
| Sall, Abraham | Edgecombe (1); 417 acres, 1760 |
| Sallee, Peter | Surry (1); 400 acres, 1782 |
| Sallen Creek (tenn.) | Davidson TN (1); 1000 acres, 1787 |
| Saller, Luke | Bertie (2); 500 acres, 1743 |
| Salley, Jacob | Surry (1); 135 acres, 1783 |
| Sallier, Benjamin | Onslow (2); 260 acres, 1736 |
| Salling, Elizabeth | Rutherford (1); 100 acres, 1789 |
| Sallis, John | Granville (4); 2014 acres, 1751-1753 |
| Salls Branch | Wake (1), Rutherford (1); total 2 grants and 715 acres, 1834-1881 |
| Sally, Jacob | Surry (1); 400 acres, 1779 |
| Sally, John | Davidson TN (1); 640 acres, 1787 |
| Sally, Thomas | Davidson TN (2); 1640 acres, 1787 |
| Sallyers, Zachariah | Burke (1); 400 acres, 1780 |
| Salmon Creek | Chowan (12), Bertie (11); total 23 grants and 17939 acres, 1712-1819 |
| Salmon, Daniel | Duplin (1); 250 acres, 1763 |
| Salmon, Elijah | Iredell (1); 64 acres, 1819 |
| Salmon, Enoch | Surry (1); 60 acres, 1825 |
| Salmon, James | Cumberland (2); 600 acres, 1760 |
| Salmon, Jonathan | Bute (1); 155 acres, 1779 |
| Salmon, S. A. | Harnett (1); 100 acres, 1888 |
| Salmon, Vincent | Tennessee TN (1); 1000 acres, 1796 |
| Salmon, William | New Hanover (1); 150 acres, 1784 |
| Salmone, Henrietta | Cumberland (1); 28 acres, 1831 |
| Salomon, Bennet | Montgomery (1); 100 acres, 1812 |
| Sals Branch | Wilkes (1); 100 acres, 1854 |
| Salsberry | Craven (1); 150 acres, 1745 |
| Salsberry Branch | Craven (6); 600 acres, 1745-1761 |
| Salsbury, Pettigrove | Johnston (1); 150 acres, 1754 |
| Salsbury, Pettygrove | Johnston (1); 150 acres, 1754 |
| Salt Beef Point | Bladen (1); 150 acres |
| Salt Boiler Point | Onslow (1); 1 acres, 1888 |
| Salt Branch | Cherokee (2); 200 acres, 1860 |
| Salt Lick Creek (tenn.) | Sumner TN (7), Davidson TN (2); total 9 grants and 7544 acres, 1788-1797 |
| Salt Licks | Davidson TN (4), Montgomery TN (1); total 5 grants and 2120 acres, 1791 |
| Salt Log Branch | Ashe (1), Wilkes (1); total 2 grants and 200 acres, 1804-1808 |
| Salt Marsh | Bladen (1); 300 acres, 1799 |
| Salt Peter Knob | Ashe (5); 315 acres, 1818-1839 |
| Salt River (tenn.) | Sumner TN (1), Davidson TN (1); total 2 grants and 1640 acres, 1795 |
| Salt Rock Creek | Henderson (1); 100 acres, 1852 |
| Salt, Abraham | Dobbs (1); 110 acres, 1774 |
| Saltar, John D. | Bladen (1); 30 acres, 1834 |
| Salter Creek | Carteret (1); 344 acres, 1811 |
| Salter, _____ | Pitt (1); 640 acres, 1772 |
| Salter, Edward | Pitt (11), Beaufort (10); total 21 grants and 8801 acres, 1750-1782 |
| Salter, George | Anson (3); 900 acres, 1753 |
| Salter, Harvey | Bladen (1); 35 acres, 1853 |
| Salter, Henry, Jr. | Carteret (1); 33 acres, 1811 |
| Salter, J. W. | Carteret (1); 4 acres, 1889 |
| Salter, James | Bladen (6), Carteret (1); total 7 grants and 929 acres, 1784-1810 |
| Salter, James, Jr. | Bladen (2); 681 acres, 1818 |
| Salter, James, Sr. | Bladen (2); 429 acres |
| Salter, John | Pitt (12), Beaufort (7), Bladen (2), plus 1 grant in 1 other county; total 22 grants and 4906 acres, 1769-1853 |
| Salter, John D. | Bladen (3); 167 acres, 1836-1841 |
| Salter, John, Jr. | Pitt (6); 3000 acres, 1798-1800 |
| Salter, Peter | Randolph (1), Moore (1); total 2 grants and 200 acres, 1789-1802 |
| Salter, Richard | Bladen (3), Carteret (1); total 4 grants and 660 acres, 1773-1810 |
| Salter, Robert | Pitt (8); 2434 acres, 1770-1802 |
| Salter, Thomas | Pitt (1); 180 acres, 1774 |
| Salter, V. B. | Carteret (1); 50 acres, 1897 |
| Salter, Van Buren | Carteret (1); 0 acres, 1882 |
| Salter, Will W. | Bladen (1); 35 acres, 1853 |
| Salter, William | Bladen (13), Carteret (10), Craven (2); total 25 grants and 4897 acres, 1735-1815 |
| Salter, William James | Bladen (1); 90 acres, 1808 |
| Salter, William, Jr. | Carteret (2); 64 acres, 1797 |
| Salter, Zachariah | Carteret (1); 10 acres, 1890 |
| Salters Lake | Bladen (1); 178 acres, 1935 |
| Salts, Anthony | Rowan (1); 285 acres, 1761 |
| Saluda (N.C.) | Mecklenburg (1); 500 acres |
| Saluda Path | Rutherford (2), Buncombe (1); total 3 grants and 360 acres, 1787-1806 |
| Saluda River | Rutherford (42); 22700 acres, 1783-1796 |
| Saluda River (S.C.) | Mecklenburg (2); 840 acres |
| Saluda Township | Polk (2); 266 acres, 1911-1912 |
| Saludy Path | Anson (2); 780 acres, 1753-1755 |
| Salyaur, Samuel, Jr. | Currituck (1); 106 acres, 1787 |
| Salyear, Samuel, Jr. | Currituck (2); 357 acres, 1815 |
| Salyear, Samuel, Sr. | Currituck (2); 12 acres, 1814 |
| Salyer, Samuel | Currituck (2); 60 acres, 1820 |
| Salyer, Samuel, Sr. | Currituck (1); 410 acres, 1812 |
| Sam's Creek | Montgomery (1); 30 acres, 1848 |
| Same, H. O. | Stokes (1); 83 acres, 1901 |
| Samerlin, Henry | Anson (1); 100 acres, 1754 |
| Sames, James | Burke (2); 400 acres, 1794 |
| Sames, Larkin | Buncombe (1); 2 acres, 1853 |
| Samford, Samuel | Dobbs (6), Tennessee TN (1), Sumner TN (1); total 8 grants and 1809 acres, 1764-1793 |
| Sammel, Henry | Surry (1); 9 acres, 1848 |
| Sammeys Neck | Bladen (1); 100 acres, 1837 |
| Sammon, John | Caswell (1); 426 acres, 1783 |
| Sammon, Lewis | Onslow (1); 1 acres, 1891 |
| Sammons, Daniel | Moore (1); 16 acres, 1818 |
| Sammons, Willoughby, Sr. | Camden (1); 45 acres, 1830 |
| Samms, William | Buncombe (1); 100 acres, 1798 |
| Sampell, Thomas | Washington TN (1); 100 acres, 1782 |
| Sample Branch | Rowan (1); 578 acres, 1789 |
| Sample, Edward | Tyrrell (1); 50 acres, 1822 |
| Sample, George | Greene TN (1); 160 acres, 1787 |
| Sample, John | Mecklenburg (1); 38 acres, 1782 |
| Sample, Joseph | Mecklenburg (2), Tryon (1); total 3 grants and 550 acres, 1768 |
| Sample, Joseph R. | Mecklenburg (1); 11 acres, 1805 |
| Sample, Robert | Tennessee TN (1); 320 acres, 1797 |
| Sample, Samuel | Hawkins TN (1), Greene TN (1); total 2 grants and 350 acres, 1787-1793 |
| Sample, William | Mecklenburg (1); 80 acres, 1768 |
| Sampler, Samuel | Greene TN (1); 150 acres, 1787 |
| Samples Mountain | Jackson (1); 50 acres, 1856 |
| Samples, Samuel | Greene TN (2); 500 acres, 1787 |
| Samples, Thomas | Washington TN (1); 100 acres, 1782 |
| Sampson County | Duplin (4), Sampson (1), New Hanover (1); total 6 grants and 870 acres, 1788-1816 |
| Sampson Mountain | Wilkes (6), Ashe (1); total 7 grants and 1915 acres, 1827-1862 |
| Sampson Swamp | Brunswick (1); 120 acres, 1788 |
| Sampson, Benjamin | Surry (1); 640 acres, 1779 |
| Sampson, David | Davidson TN (1); 640 acres, 1793 |
| Sampson, Hardy | Onslow (1); 15 acres, 1891 |
| Sampson, James | Sampson (3), Duplin (3), Middle District TN (1); total 7 grants and 3535 acres, 1788-1797 |
| Sampson, Jane | Sampson (1); 6 acres |
| Sampson, Joab | Sumner TN (1); 640 acres, 1793 |
| Sampson, John | Duplin (14), New Hanover (8), Bladen (4), plus 5 grants in 4 other counties; total 31 grants and 15576 acres, 1747-1793 |
| Sampson, Moseley | New Hanover (1); 300 acres |
| Sampson, Richard | Onslow (1); 100 acres, 1816 |
| Sampson, William | Davidson TN (1); 640 acres, 1794 |
| Sampsons Bluff | Duplin (2); 200 acres, 1756 |
| Sampsons Branch | New Hanover (2); 1200 acres, 1745 |
| Sampsons Fork | Burke (1); 50 acres, 1801 |
| Sampsons Landing | Duplin (2); 400 acres, 1759 |
| Sams Branch | Wilkes (3), Yancey (2), Anson (1), plus 3 grants in 3 other counties; total 9 grants and 923 acres, 1768-1894 |
| Sams Creek | Johnston (9), Montgomery (3), McDowell (2), plus 5 grants in 4 other counties; total 19 grants and 4445 acres, 1779-1878 |
| Sams Creek (tenn.) | Davidson TN (3); 1920 acres, 1793-1797 |
| Sams, Ben | Buncombe (1); 300 acres, 1808 |
| Sams, Benoni | Buncombe (1); 200 acres |
| Sams, Burdet | Buncombe (5); 685 acres, 1803 |
| Sams, Burdit | Buncombe (3); 262 acres, 1798-1807 |
| Sams, Burdite | Buncombe (1); 118 acres, 1811 |
| Sams, David | Buncombe (1); 23 acres, 1844 |
| Sams, Edmond | Buncombe (2); 600 acres, 1808 |
| Sams, Edmund | Buncombe (3); 240 acres, 1811-1824 |
| Sams, Edward | Buncombe (4); 325 acres, 1796-1810 |
| Sams, Gabriel | Yancey (1); 100 acres |
| Sams, James | Yancey (1); 40 acres, 1844 |
| Sams, John P. | Yancey (1); 100 acres, 1844 |
| Sams, Larkin | Buncombe (1); 100 acres, 1840 |
| Sams, Lee | Buncombe (1); 200 acres |
| Sams, Peter | Wilkes (1); 19 acres, 1840 |
| Sams, Reuben | Burke (2); 100 acres, 1813 |
| Sams, Rice | Eastern District TN (1); 200 acres, 1793 |
| Sams, Rue | Washington TN (1); 100 acres, 1784 |
| Sams, Walter | Craven (1); 270 acres, 1746 |
| Sams, Warren | Buncombe (3); 500 acres, 1818-1832 |
| Sams, William | Burke (2); 244 acres, 1792 |
| Samson, John | New Hanover (1); 640 acres |
| Samson, Micajah | Burke (1); 160 acres, 1790 |
| Samuel Bay | Tyrrell (4); 360 acres, 1834-1837 |
| Samuel Sherrill and Co. | Macon (6); 3300 acres, 1855 |
| Samuel, Anthony | Caswell (1); 510 acres, 1779 |
| Samuel, Henry | Surry (1); 48 acres, 1835 |
| Samuel, Mosby | Surry (1); 640 acres, 1780 |
| Samuel, Scott | Buncombe (1); 150 acres |
| Samuels Creek | Craven (1); 20 acres, 1789 |
| Samuels, Gideon | Tyrrell (1); 590 acres, 1784 |
| San Creek | Wilkes (1); 59 acres, 1845 |
| Sanborn, C. H. | Carteret (1); 300 acres, 1888 |
| Sanborn, Phineas | Camden (1); 50 acres, 1829 |
| Sand Branch | Rutherford (2), Burke (1); total 3 grants and 300 acres, 1821-1835 |
| Sand Creek | Anson (1); 50 acres, 1783 |
| Sand Ford Branch | Richmond (1); 100 acres, 1851 |
| Sand Hill Bluff | Robeson (1); 150 acres, 1804 |
| Sand Hill Branch | Duplin (6), Sampson (1); total 7 grants and 700 acres, 1766-1811 |
| Sand Hill Cove | New Hanover (2); 200 acres, 1750 |
| Sand Hill Creek | Brunswick (1); 62 acres, 1852 |
| Sand Hill Mill Branch | Cumberland (1); 200 acres, 1770 |
| Sand Hill Township | Scotland (1); 19 acres, 1903 |
| Sand Hills | Sampson (1); 24 acres, 1891 |
| Sand Ridge | Craven (1); 72 acres, 1787 |
| Sand Ridge Bay | Bladen (1); 100 acres, 1787 |
| Sand Run | Rowan (1); 222 acres, 1789 |
| Sander, Alexander | Craven (1); 292 acres, 1772 |
| Sander, John | Macon (1), Craven (1); total 2 grants and 200 acres, 1769-1853 |
| Sanderfer, John | Wayne (1); 239 acres, 1786 |
| Sanderford Family | Yancey (1); 50 acres, 1835 |
| Sanderfur, John | Hertford (1); 118 acres, 1780 |
| Sanderlan, Mary | Pasquotank (1); 436 acres, 1761 |
| Sanderlin, Daniel G. | Dare (1); 7 acres, 1878 |
| Sanderlin, David | Sumner TN (1); 640 acres, 1793 |
| Sanderlin, Elihu | Tyrrell (1); 97 acres, 1836 |
| Sanderlin, Isaac | Sumner TN (1); 640 acres, 1793 |
| Sanderlin, John | Tyrrell (4); 225 acres, 1823 |
| Sanderlin, Levi | Sumner TN (1); 228 acres, 1793 |
| Sanderlin, Lewis | Sumner TN (1); 228 acres, 1793 |
| Sanderlin, Samuel, Jr. | Duplin (1); 216 acres, 1790 |
| Sanderlin, Thomas M. | Dare (1); 7 acres, 1878 |
| Sanderline, Frainagan | Tyrrell (1); 100 acres, 1834 |
| Sanderlins Swamp | Camden (1); 50 acres, 1795 |
| Sanders Branch | Wake (1), Caswell (1); total 2 grants and 800 acres, 1780-1783 |
| Sanders Creek | Moore (7), Onslow (2), Carteret (1); total 10 grants and 1221 acres, 1788-1889 |
| Sanders Joseph | Randolph (1); 337 acres, 1787 |
| Sanders, A. H. | Montgomery (1); 100 acres, 1853 |
| Sanders, Aaron | Anson (3), Montgomery (2), Caldwell (2); total 7 grants and 907 acres, 1773-1879 |
| Sanders, Alexander | Richmond (1); 16 acres, 1829 |
| Sanders, Alexander H. | Richmond (1); 36 acres, 1828 |
| Sanders, Andrew | Beaufort (1), Sumner TN (1); total 2 grants and 438 acres, 1798 |
| Sanders, Applewhite | Davidson TN (1); 640 acres, 1789 |
| Sanders, Ascum | Anson (1); 75 acres, 1833 |
| Sanders, B. J. | Wilkes (1); 94 acres, 1873 |
| Sanders, B. L. | Montgomery (3); 228 acres, 1852-1854 |
| Sanders, Bailey | Montgomery (1); 100 acres, 1837 |
| Sanders, Benjamin | Montgomery (3), Randolph (2), Perquimans (1), plus 1 grant in 1 other county; total 7 grants and 705 acres, 1789-1832 |
| Sanders, Benjamin, Jr. | Perquimans (1); 2 acres, 1791 |
| Sanders, Britain | Wake (1); 400 acres, 1780 |
| Sanders, Brittain L. | Montgomery (1); 30 acres, 1852 |
| Sanders, Charles | Onslow (2), Craven (2), Jackson (1); total 5 grants and 900 acres, 1761-1883 |
| Sanders, Charles, Jr. | Craven (2); 220 acres, 1793 |
| Sanders, D. W. | Onslow (2), Montgomery (2); total 4 grants and 888 acres, 1850-1933 |
| Sanders, Daniel | Duplin (2); 200 acres, 1757 |
| Sanders, David S. | New Hanover (2); 193 acres, 1845-1858 |
| Sanders, David W. | Onslow (1); 100 acres, 1854 |
| Sanders, E. | Macon (1), Jackson (1); total 2 grants and 150 acres, 1854-1859 |
| Sanders, E. J. | Cherokee (1); 50 acres, 1855 |
| Sanders, Edward | Lincoln (1), Robertson TN (1); total 2 grants and 840 acres, 1796-1809 |
| Sanders, Elisha | Jackson (5), Macon (1); total 6 grants and 430 acres, 1854-1874 |
| Sanders, Elisha, Jr. | Jackson (1); 100 acres, 1883 |
| Sanders, Elizabeth | Macon (2); 125 acres, 1841-1852 |
| Sanders, Ephraim | Lenoir (1); 20 acres, 1800 |
| Sanders, Francis | Rowan (1), Carteret (1), Wilkes (1); total 3 grants and 550 acres, 1784-1785 |
| Sanders, Franky | Hyde (2); 100 acres, 1763 |
| Sanders, George | Anson (1); 100 acres, 1773 |
| Sanders, Hardy | Wake (8), Moore (5), Orange (1), plus 2 grants in 2 other counties; total 16 grants and 3540 acres, 1761-1859 |
| Sanders, Hearman | Surry (1); 250 acres, 1797 |
| Sanders, Henderson | Macon (3); 225 acres, 1836-1853 |
| Sanders, Henry | Montgomery (2), Rutherford (1), Macon (1); total 4 grants and 450 acres, 1792-1894 |
| Sanders, Hezekiah | Guilford (4); 500 acres, 1786-1789 |
| Sanders, Ira | Randolph (1); 17 acres, 1874 |
| Sanders, Isaac | Onslow (5); 200 acres, 1804-1816 |
| Sanders, Isaac N. | Onslow (1); 100 acres, 1852 |
| Sanders, Isham | Moore (1); 4 acres, 1873 |
| Sanders, J. A. | Macon (2); 348 acres, 1878-1902 |
| Sanders, J. A. T. | Macon (2); 43 acres, 1901-1905 |
| Sanders, J. H. | Montgomery (1); 26 acres, 1890 |
| Sanders, J. W. | Onslow (1); 120 acres, 1900 |
| Sanders, Jacob | Montgomery (4); 400 acres, 1803-1820 |
| Sanders, James | Sumner TN (22), Davidson TN (11), Surry (6), plus 26 grants in 13 other counties; total 65 grants and 24838 acres, 1757-1869 |
| Sanders, James T. | Chatham (1); 53 acres, 1849 |
| Sanders, James, Jr. | Sumner TN (2), Davidson TN (1); total 3 grants and 1744 acres, 1786-1798 |
| Sanders, Jesse | Macon (3), Stokes (2), Onslow (2), plus 4 grants in 3 other counties; total 11 grants and 992 acres, 1789-1847 |
| Sanders, Joanah | Montgomery (1); 50 acres, 1803 |
| Sanders, Job | Davidson TN (1); 640 acres, 1789 |
| Sanders, Joel | Anson (3), Guilford (3), Surry (1), plus 1 grant in 1 other county; total 8 grants and 2193 acres, 1775-1806 |
| Sanders, John | Carteret (7), Johnston (5), Onslow (4), plus 21 grants in 14 other counties; total 37 grants and 6598 acres, 1727-1882 |
| Sanders, John A. | Onslow (1), New Hanover (1); total 2 grants and 516 acres, 1837-1859 |
| Sanders, John A. T. | Macon (1); 403 acres, 1885 |
| Sanders, John M. | Cherokee (2); 150 acres, 1855-1856 |
| Sanders, John, Jr. | Carteret (2), Nash (1); total 3 grants and 230 acres, 1762-1801 |
| Sanders, Joseph | Randolph (2), Dobbs (1), Wilkes (1), plus 1 grant in 1 other county; total 5 grants and 617 acres, 1779-1854 |
| Sanders, Julias | Davidson TN (1), Wilkes (1); total 2 grants and 328 acres, 1789-1802 |
| Sanders, Julius | Davidson TN (5), Sumner TN (3), Tennessee TN (1); total 9 grants and 4456 acres, 1786-1795 |
| Sanders, Kerby | Franklin (1); 334 acres, 1780 |
| Sanders, L. E. | Onslow (1); 80 acres, 1878 |
| Sanders, Lewis | New Hanover (1); 192 acres, 1855 |
| Sanders, Luke | Montgomery (3), Granville (1); total 4 grants and 270 acres, 1780-1806 |
| Sanders, M. S. | Alleghany (1); 41 acres, 1874 |
| Sanders, Mary | Montgomery (1), Johnston (1), Sumner TN (1); total 3 grants and 880 acres, 1790-1830 |
| Sanders, Mason | Rockingham (1); 44 acres, 1812 |
| Sanders, Milly | Richmond (1); 200 acres, 1797 |
| Sanders, Moses | Anson (4), Jones (1); total 5 grants and 1570 acres, 1773-1785 |
| Sanders, Nathaniel | Bladen (4), Anson (1); total 5 grants and 400 acres, 1768 |
| Sanders, Nimrod | Montgomery (1); 100 acres, 1804 |
| Sanders, P. C. | Montgomery (3); 209 acres, 1858-1890 |
| Sanders, Patrick | Anson (3); 700 acres, 1767-1775 |
| Sanders, R. M. | Macon (1); 0 acres |
| Sanders, Rachel | Surry (1); 200 acres, 1780 |
| Sanders, Reuben | Johnston (1); 28 acres, 1795 |
| Sanders, Richard | Duplin (3), Caswell (2), Surry (1), plus 4 grants in 4 other counties; total 10 grants and 2074 acres, 1762-1879 |
| Sanders, Robert | Rowan (3), Craven (2), Pitt (1), plus 2 grants in 2 other counties; total 8 grants and 1227 acres, 1765-1798 |
| Sanders, Romulous | Macon (1); 4 acres, 1900 |
| Sanders, S. L. | Transylvania (2); 115 acres, 1892 |
| Sanders, Samuel | Carteret (15), Davidson TN (1); total 16 grants and 2030 acres, 1765-1809 |
| Sanders, Simeon | Onslow (3); 300 acres, 1854-1855 |
| Sanders, Simeon E. | Onslow (2); 112 acres, 1855-1873 |
| Sanders, Simon | Onslow (1); 100 acres, 1840 |
| Sanders, Solomon | Jones (1); 198 acres, 1782 |
| Sanders, Stephen | Montgomery (2); 250 acres, 1799-1803 |
| Sanders, T. A. | Macon (1); 250 acres, 1878 |
| Sanders, Thomas | Nash (2), Macon (1), Edgecombe (1), plus 3 grants in 3 other counties; total 7 grants and 1840 acres, 1779-1850 |
| Sanders, W. C. | Macon (7); 680 acres, 1891-1902 |
| Sanders, W. E. | Macon (2); 41 acres, 1902-1914 |
| Sanders, W. P. | Rockingham (1); 14 acres, 1879 |
| Sanders, Wilburn | Macon (1); 63 acres, 1853 |
| Sanders, Wilburn, Jr. | Macon (1); 100 acres, 1855 |
| Sanders, William | Davidson TN (9), Sumner TN (6), Johnston (2), plus 12 grants in 11 other counties; total 29 grants and 15604 acres, 1760-1855 |
| Sanders, William A. | Cherokee (1); 100 acres, 1857 |
| Sanders, William I. | Onslow (1); 65 acres, 1855 |
| Sanders, William M. | Cherokee (1); 50 acres, 1855 |
| Sanders, William P. | Onslow (3); 166 acres, 1854-1872 |
| Sanders, William R. | Caldwell (1); 50 acres, 1854 |
| Sanders, William W. | Montgomery (1); 100 acres, 1844 |
| Sanders, William, Jr. | Onslow (1); 100 acres |
| Sanderson, Benjamim | Jones (1); 50 acres, 1809 |
| Sanderson, Benjamin | Jones (2), Currituck (1); total 3 grants and 308 acres, 1763-1809 |
| Sanderson, Eli | Cherokee (15), Macon (3), Clay (1); total 19 grants and 2371 acres, 1839-1874 |
| Sanderson, Elijah | Jones (1); 33 acres, 1810 |
| Sanderson, Jesse | Currituck (3), Tyrrell (1); total 4 grants and 927 acres, 1782-1845 |
| Sanderson, John | Hyde (4), Currituck (3), Tyrrell (1); total 8 grants and 2789 acres, 1696-1845 |
| Sanderson, John B. | Clay (1); 1 acres, 1896 |
| Sanderson, John, Sr. | Currituck (1); 60 acres, 1782 |
| Sanderson, Jonathan | Craven (3); 420 acres, 1749-1765 |
| Sanderson, Joseph | Currituck (8), Craven (4); total 12 grants and 2671 acres, 1712-1774 |